MOTS-c — Mitochondrial-Derived Peptide for Metabolic Research
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide encoded by the mitochondrial 12S rRNA gene. It has emerged as a critical regulator of metabolic homeostasis, acting as a mitochondrial signal that influences nuclear gene expression to control metabolism, insulin sensitivity, and adaptive responses to metabolic stress.
Key Specifications
- CAS Number: 1627580-64-6
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: 2174.62 g/mol
- Purity: 99% (HPLC verified)
- Appearance: White lyophilized powder
- Reconstitution: Required
- Storage: 2–8°C (lyophilized), -20°C (reconstituted)
- Available Sizes: 10mg, 40mg per vial
Research Applications
- Mitochondrial-nuclear communication and retrograde signaling
- Metabolic flexibility and glucose utilization
- AMPK pathway activation and energy metabolism
- Exercise mimetic and metabolic adaptation research
- Age-related metabolic decline
- Obesity and insulin resistance mechanisms
Frequently Asked Questions
What makes MOTS-c unique among research peptides?
MOTS-c is one of the few known peptides encoded by mitochondrial DNA rather than nuclear DNA. It acts as a retrograde signal from mitochondria to the nucleus, regulating gene expression related to metabolism and cellular stress responses.
What research areas benefit from MOTS-c?
MOTS-c is particularly valuable in metabolic research, mitochondrial biology, aging studies, and investigations of exercise physiology at the molecular level.
Reviews
There are no reviews yet.