What Is Mots-C?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by the mitochondrial 12S rRNA gene. Unlike most peptides that originate from nuclear DNA, MOTS-c is produced from mitochondrial genetic material, making it a unique tool for studying mitochondrial-nuclear communication. CAS number 1627580-64-6, molecular weight 2174.62, purity 99 percent.
Mitochondrial Retrograde Signaling
MOTS-c acts as a retrograde signal from mitochondria to the nucleus. Under metabolic stress conditions, MOTS-c translocates to the nucleus and regulates the expression of genes involved in metabolic adaptation, glucose utilization, and cellular stress responses. This mechanism represents a fundamental pathway by which mitochondria communicate their functional status to the nuclear genome.
Key Specifications at G25
G25 MOTS-c is supplied as white lyophilized powder with 99 percent purity verified by independent HPLC and MS. Available in 10mg and 40mg vial sizes. Requires reconstitution before use. After reconstitution, store at 2 to 8 degrees Celsius.
Research Applications
MOTS-c supports investigations in mitochondrial-nuclear communication, metabolic flexibility and glucose utilization, AMPK pathway activation, exercise mimetic research, age-related metabolic decline, and obesity and insulin resistance mechanisms.
Why MOTS-c Matters
As one of the few known mitochondrial-encoded peptides with systemic metabolic effects, MOTS-c opens new research directions in mitochondrial biology, aging, and metabolic disease.