What Is ACE 031?
ACE 031 is a soluble Activin Receptor Type IIB (ActRIIB) fusion protein that functions as a ligand trap for myostatin (GDF-8) and related TGF-beta superfamily ligands. By sequestering these negative regulators of muscle growth, ACE 031 serves as a powerful research tool for investigating muscle hypertrophy, regeneration, and neuromuscular disease mechanisms.
How ACE 031 Works at the Molecular Level
ACE 031 acts as a decoy receptor. It binds circulating myostatin and activin A, preventing these ligands from interacting with endogenous ActRIIB receptors on muscle cell surfaces. This relieves the tonic inhibition on muscle protein synthesis pathways, allowing researchers to study unimpeded muscle growth signaling. The ACVR2B-Fc architecture provides high binding affinity and extended circulating duration in research models.
Key Specifications at G25
G25 ACE 031 is supplied as a white lyophilized powder with purity exceeding 99 percent verified by independent HPLC and MS. This product is classified as a lyophilized powder for research use only. Full Certificates of Analysis including HPLC chromatograms and mass spectra are provided upon request.
Research Applications
ACE 031 supports investigations in muscle hypertrophy and atrophy mechanisms, myostatin signaling pathway analysis, muscular dystrophy and related neuromuscular disease models, sarcopenia and age-related muscle loss, cachexia in chronic disease models, and satellite cell activation and muscle stem cell biology.
Significance in Muscle Research
The myostatin pathway is one of the most important regulatory systems in muscle biology. By providing a tool to selectively inhibit this pathway, ACE 031 enables researchers to dissect the molecular mechanisms controlling muscle mass with precision.