ACE-031 — Myostatin Inhibitor for Muscle Research
ACE-031 is a soluble Activin Receptor Type IIB (ActRIIB) fusion protein that functions as a ligand trap for myostatin and related TGF-beta superfamily ligands. By sequestering these negative regulators of muscle growth, ACE-031 serves as a powerful research tool for investigating muscle hypertrophy, regeneration, and neuromuscular disease mechanisms.
Key Specifications
- Type: ACVR2B-Fc fusion protein (ActRIIB ligand trap)
- Target: Myostatin (GDF-8) and related ligands
- Purity: >99%
- Appearance: White lyophilized powder
- Classification: Lyophilized powder for research
Research Applications
- Muscle hypertrophy and atrophy mechanisms
- Myostatin signaling pathway analysis
- Muscular dystrophy and cachexia models
- Satellite cell activation and muscle stem cell biology
- Sarcopenia and age-related muscle loss
Frequently Asked Questions
How does ACE-031 work at the molecular level?
ACE-031 acts as a decoy receptor for myostatin (GDF-8) and activin A, preventing these ligands from binding to endogenous ActRIIB receptors on muscle cells. This relieves the negative regulation on muscle protein synthesis, allowing researchers to study unimpeded muscle growth pathways.
What research models benefit from ACE-031?
ACE-031 is primarily used in muscle biology research, including studies of hypertrophy, atrophy reversal, neuromuscular disorders, and the molecular mechanisms of muscle wasting conditions.
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