5-Amino-1MQ — NNMT Inhibitor for Metabolic Research
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a potent, selective small-molecule inhibitor of Nicotinamide N-Methyltransferase (NNMT). NNMT regulates cellular energy metabolism by controlling the methylation of nicotinamide, affecting NAD+ biosynthesis and SAM/SAH ratios. 5-Amino-1MQ is a valuable tool for investigating metabolic reprogramming, adipocyte biology, and energy homeostasis.
Key Specifications
- Type: Small molecule NNMT inhibitor
- Dosage Form: 5mg per vial
- Purity: >99%
- Classification: Lyophilized powder for research
- Storage: 2-8°C, protected from light
Research Applications
- NNMT enzymatic activity and inhibition kinetics
- Adipocyte differentiation and lipid metabolism
- NAD+ biosynthesis and cellular energy metabolism
- Metabolic reprogramming in obesity and diabetes
- Cancer cell metabolism and epigenetics
Frequently Asked Questions
What is the significance of NNMT inhibition in research?
NNMT consumes methyl groups from S-adenosylmethionine (SAM) to methylate nicotinamide. By inhibiting NNMT, 5-Amino-1MQ increases cellular NAD+ levels and alters the cellular methylation potential, providing insights into metabolic and epigenetic regulation.
What purity does RA101 guarantee for 5-Amino-1MQ?
All batches undergo independent HPLC and MS verification at >99% purity. Certificates of analysis are available upon request.
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