What Is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a potent, selective small-molecule inhibitor of Nicotinamide N-Methyltransferase (NNMT). Unlike the peptide products in the G25 catalog, 5-Amino-1MQ is a small molecule that targets a specific enzymatic pathway controlling cellular energy metabolism and epigenetic regulation.
NNMT and Metabolic Regulation
NNMT catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. This reaction consumes methyl groups and produces 1-methylnicotinamide (1-MNA), simultaneously depleting the cellular pool of NAD plus precursors and altering the SAM to SAH ratio that governs cellular methylation potential. By inhibiting NNMT, 5-Amino-1MQ increases NAD plus levels and shifts the cellular methylation landscape, providing insights into the intersection of metabolism and epigenetics.
Key Specifications at G25
G25 5-Amino-1MQ is supplied as a lyophilized powder in 5mg vials with purity exceeding 99 percent verified by independent HPLC and MS. Storage at 2 to 8 degrees Celsius protected from light. This product is classified as a lyophilized powder for research use only.
Research Applications
5-Amino-1MQ supports investigations in NNMT enzymatic activity and inhibition kinetics, adipocyte differentiation and lipid metabolism, NAD plus biosynthesis and cellular energy metabolism, metabolic reprogramming in obesity and diabetes, and cancer cell metabolism and epigenetics.
Why NNMT Inhibition Matters
NNMT has emerged as a critical regulator at the intersection of metabolism and epigenetics. By controlling the availability of methyl groups and NAD plus precursors, NNMT influences processes ranging from adipocyte differentiation to cancer cell proliferation. 5-Amino-1MQ provides researchers with a selective tool to probe these mechanisms.